Retrospective analysis of patients with hereditary nonpolyposis colorectal cancer (HNPCC)
نویسندگان
چکیده
We performed a one–center cohort retrospective analysis of 1378 non-selected patients operated for colorectal cancer (CRC) in the years 1994 – 2013. For the purpose of this study we divided patients into three subdivisions reflecting their family history of HNPCC–associated cancers among firstand second-degree relatives. On detailed pedigree analysis of the families we identified 59 patients as being affected with HNPCC (4.28%). Compared with other CRC patients our HNPCC subjects were significantly younger at time of diagnosis (median age 51 years, p < 0.05), were more likely to present with right–sided tumors rather than with rectal ones (p < 0.05). Synchronous tumors were found in 45 CRC patients (3.27%), of whom HNPCC subjects were predominant (8.47 vs. 3.03%, p= 0.02). HNPCC patients were also more likely to receive radical resection surgery compared with other CRC patients (93.22% vs. 86.73%). Patients with HNPCC presented with more favorable staging and more frequent mucinous component on histological examination. Overall survival was statistically longer in HNPCC than in other CRC patients (45 vs. 25 months, p =0.01806). Submitted data and our experience in colorectal surgery made us to support conclusion corroborated by literature evidence and regarding fine distinction between HNPCC and sporadic CRC patients.
منابع مشابه
Evaluation of MLH1 and MSH2 Gene Mutations in a Subset of Iranian Families with Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
متن کامل
Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies
Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...
متن کاملMolecular Analysis of Microsatellite Instability in Hereditary Non Polyposis Colon Carcinoma Patients from North-East Iran
Background and Objectives: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. Tumors arising as a result of these mutations display instability in a sequence area known as microsatellites. Studies have shown that some Bethesda markers (BAT25, BAT26) are more efficient than other...
متن کاملTobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome).
BACKGROUND The marked variability in age at onset of colorectal cancer (CRC) in patients with hereditary nonpolyposis colorectal cancer (HNPCC) makes management decisions difficult. Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated. METHODS We determined whether tobacco use would alter CRC risk in carriers of HNPCC...
متن کاملReplication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.
A replication error (RER) phenotype has been documented both in sporadic colorectal tumors and in tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC). In the current study 8 of 49 (16%) sporadic colorectal cancers (CRCs) and 25 of 29 (86%) CRCs from HNPCC patients were found to be RER+. All 9 (100%) CRCs from HNPCC patients with germline mutations of the mismatch repair ...
متن کامل